A research paper on the nature effects and treatment of phenylketonuria pku

All Non-IgE Mediated Immune System Responses to Food, being slower acting, are classed as being Food Intolerances, a term which includes other types of slow reaction included a lack of necessary enzymes and toxicological responses etc. Of course, IgE and non-IgE immune responses can occur within the same patient to the same food type, but at slightly different times, i. Wikipedia defines Food Allergy according to three groups: IgA, IgG and IgM reactions Some of the latter two groups are hereditary genetic in nature, others are merely conditioned or acquired.

A research paper on the nature effects and treatment of phenylketonuria pku

All Non-IgE Mediated Immune System Responses to Food, being slower acting, are classed as being Food Intolerances, a term which includes other types of slow reaction included a lack of necessary enzymes and toxicological responses etc.

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Of course, IgE and non-IgE immune responses can occur within the same patient to the same food type, but at slightly different times, i.

Wikipedia defines Food Allergy according to three groups: IgA, IgG and IgM reactions Some of the latter two groups are hereditary genetic in nature, others are merely conditioned or acquired. Secondary Immune System Response to Food could also be another possible term, although perhaps less formal and precise than the above.

The severity of the different immunological reactions to food differ between foods, and between individuals, as well as how they combine with other Food Intolerance and other factors. Their combined action may provide the broad spectrum of symptoms that we experience as Food Intolerance.

And indeed, they can also exacerbate a downward spiral of General Digestive Enzyme and Stomach Acid Deficiencies and indeed the other types of Food Intolerance. The reactions are based on the misrecognition of certain types of protein as viral DNA proteins, the same as Classic Food Allergies.

Metabolomic methods

Unresponsiveness of the immune system to dietary antigens is termed "oral tolerance" and is believed to involve the deletion or switching off of reactive antigen-specific T cells and the production of regulatory T cells T reg that quell inflammatory responses to benign antigens. Each IgG has two antigen binding sites.

IgG molecules are synthesised and secreted by plasma B cells. Most occurrences are very mild and go undetected or relatively symptomless which is a matter of perception in many individuals with a less than perfect diet and lifestyle.

Many may choose to ignore the presence of some of the milder IgG reactions, and pay attention and make dietary changes accordingly when they are found to have more severe IgG reactions to certain food types. IgG-mediated immune reactions to food tend to occur in some of the food types that we consume most regularly, but as a species are not perhaps best physiologically adapted to e.

IgG antibodies are found in those individuls who do not have significant food intolerances who do not notice any symptoms. Of course the foods that create these Non-IgE-Mediated Immunological Food Intolerance reactions do so in their protein form, which is the non-digested or semi-digested form, in the digestive tract, and what is absorbed into the bloodstream is hopefully only amino acids assuming that Leaky Gut Syndrome LGS is not present.

A research paper on the nature effects and treatment of phenylketonuria pku

In addition, LGS is one potential downstream consequence of too much immune system regulated inflammation in the digestive tract, caused by excessive Eosinophil hyperactivity and inflammatory cytokines being released by them.

LGS is examined in more detail on the Digestive Disorders page. Therefore one would assume that the majority of IgG antibodies would be present in the digestive tract rather than in the blood, although in more severe cases, the levels may well rise higher in the blood.

Some commentators have criticised IgG blood tests as they often come back negative when the actual picture in the body as a whole, and also the digestive tract, tells a different story. YorkTest states that Food Intolerance can be detected by measuring IgG antibodies in th blood, in their Foodscan Food Intolerance Test report, which is a test for IgG antibody reaction to food types.

It is presented as a Food Intolerance Test, but it is really just tested one aspect of Food Intolerance - which is still useful, but it is more of an introductory type test into Food Intolerance.

YorkTest also state that Food Sensitivity can also arise from mechanisms that do not involve the immune system, such as enzyme deficiencies e. YorkTest use the terms Food Intolerance and Food Sensitivity interchangeably, the latter being arguably a more ambiguous term.

IgA in the mucosal linings are larger in number than all other types of antibodies combined.

A research paper on the nature effects and treatment of phenylketonuria pku

Between 3g and 5g is secreted into the intestinal lumen every day. The secretory part protects the immunoglobulin from being degraded by proteolytic enzymes, e. They are secreted by the intestinal walls into the intestinal lumen the hollow centre of the intestines and mix in with the Chyme and Stool, which passes through the GI tract, slowly being digested, before being expelled from the body via the anus.

IgA antibodies cannot be readily reabsorbed from the digestive tract. The purpose of these antibodies is to combine with any detected protein threats, interpreted to be of viral origin, in order to neutralise them and prevent them being absorbed from the GI tract into the bloodstream.

This may well result in some of the IBS type symptoms as unabsorbed proteins are fermented by bacteria in the colon. Antibodies operate in a kind of lock and key manner, matching the exact type of protein they are created to bind with. The immune cells of the digestive tract comprise the largest body of immune cells in the body.

The GI tract has an enormous surface area and is arguably one of the main possible mode of entry into the body by foreign pathogens, perhaps even more so than the lungs. Without IgA antibodies being released into the digestive tract, one would be highly susceptible to gastro-intestinal viruses and other forms of infection, e.

Certain individuals in tests have been shown to produce very few IgA antibodies, which is of course an immune system deficiency. However in Food Intolerance patients, the level of IgA antibodies tends to be elevated, that is only the IgA antibodies that correspond to certain food types.Fake News Papers Fake News Videos.

Metabolomic data

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Food Allergy, Intolerance & Sensitivity